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Article

Identification of HLA-DQA1 as a Susceptibility Gene for Spinal Tuberculosis by Exome Sequencing.

Medical science monitor : international medical journal of experimental and clinical research - 24 May 2018

Shen Jian, Shi Shiyuan, Lai Zhen

Abstract excerpt

BACKGROUND Spinal tuberculosis (STB) is the main cause of bone and joint tuberculosis. This study aimed to screen and analyze the susceptibility genes for STB using whole-exome sequencing (WES). MATERIAL AND METHODS All exon regions of peripheral blood DNA from 6 STB patients were captured and sequenced using WES and the sequencing data were analyzed by modern bioinformatics methods to identify disease-causing...

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PMID: 29795056
DOI: 10.12659/MSM.907864
PMCID: PMC5994962

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