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Article

Dendritic cells combined with tumor cells and α-galactosylceramide induce a potent, therapeutic and NK-cell dependent antitumor immunity in B cell lymphoma.

Journal of translational medicine - 26 May 2017

Escribà-Garcia Laura, Alvarez-Fernández Carmen, Tellez-Gabriel Marta, Sierra Jorge, Briones Javier

Abstract excerpt

BACKGROUND: Invariant natural killer T (iNKT) cells are a small population of lymphocytes with unique specificity for glycolipid antigens presented by non-polymorphic CD1d receptor on dendritic cells (DCs). iNKT cells play a central role in tumor immunology since they are implicated in the coordination of innate and adaptive immune responses. These cells can be activated with the prototypic lipid...

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Share to Antigens, CD1d
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28549432
DOI: 10.1186/s12967-017-1219-3
PMCID: PMC5446707

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