Article
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2004
Andersen Jannik N, Jansen Peter G, Echwald Søren M, Mortensen Ole H, Fukada Toshiyuki, Del Vecchio Robert, Tonks Nicholas K, Møller Niels Peter H
Abstract excerpt
The protein tyrosine phosphatases (PTPs) are now recognized as critical regulators of signal transduction under normal and pathophysiological conditions. In this analysis we have explored the sequence of the human genome to define the composition of the PTP family. Using public and proprietary sequence databases, we discovered one novel human PTP gene and defined chromosomal loci and exon structure of the...
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