Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).

The Journal of biological chemistry - 23 Dec 2011

Lin Shu, Yu Lan, Yang Junhua, Liu Zhao, Karia Bijal, Bishop Alexander J R, Jackson James, Lozano Guillermina, Copland John A, Mu Xiaoxin, Sun Beicheng, Sun Lu-Zhe

Abstract excerpt

Biomarkers are lacking for identifying the switch of transforming growth factor-β (TGF-β) from tumor-suppressing to tumor-promoting. Mutated p53 (mp53) has been suggested to switch TGF-β to a tumor promoter. However, we found that mp53 does not always promote the oncogenic role of TGF-β. Here, we show that endogenous mp53 knockdown enhanced cell migration and phosphorylation of ERK in DU145 prostate cancer cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Shc Signaling Adaptor Proteins

Share to Smad Proteins

Share to Smad2 Protein

Share to Smad3 Protein

Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 22039050
DOI: 10.1074/jbc.M111.265397
PMCID: PMC3243540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).PMID 22039050Read ↗

Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Semantic proximity Read ↗

p53 brings a new twist to the Smad signaling network.Semantic proximity Read ↗

p53 regulates cytoskeleton remodeling to suppress tumor progression.Semantic proximity Read ↗

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.Semantic proximity Read ↗

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.Semantic proximity Read ↗

Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type IISemantic proximity Read ↗

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcriptionSemantic proximity Read ↗

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional programSemantic proximity Read ↗

Smad phosphoisoform signaling specificity: the right place at the right timeSemantic proximity Read ↗

Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions.Semantic proximity Read ↗

Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathwaySemantic proximity Read ↗

Mutant p53 drives invasion by promoting integrin recycling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.