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Article

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015

Dasgupta Maupali, Dermawan Josephine Kam Tai, Willard Belinda, Stark George R

Abstract excerpt

Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same enzymes that also modify histones, with important functional consequences. We have identified a previously unrecognized dimethylation of K49 of STAT3 that is crucial for the expression of many IL-6-dependent genes, catalyzed by the histone-modifying enzyme enhancer of zeste homolog 2 (EZH2). Loss of EZH2 is protumorigenic in...

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Identifiers

PMID: 25767098
DOI: 10.1073/pnas.1503152112
PMCID: PMC4386339

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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