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How to avoid the problem of erythrocyte alloimmunization in sickle cell disease

10 Dec 2021

Abstract excerpt

Erythrocyte alloimmunization is a major barrier to transfusion in sickle cell disease (SCD) because it can lead to transfusion deadlock and the development of life-threatening hemolytic transfusion reactions (HTRs). Several risk factors have been identified, such as blood group polymorphism in these patients of African ancestry frequently exposed to antigens they do not carry and an inflammatory clinical state of...

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PMID: 34889373
DOI: 10.1182/hematology.2021000306

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