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Article

Whole-blood phenotyping to assess alloimmunization status in transfused sickle cell disease patients.

Blood advances - 9 Mar 2021

Tamagne Marie, Pakdaman Sadaf, Bartolucci Pablo, Habibi Anoosha, Galactéros Frédéric, Pirenne France, Vingert Benoît

Abstract excerpt

It is essential to limit hemolytic transfusion reactions in polytransfused individuals, and the prevention of alloimmunization is a key solution. CD4+ T lymphocyte (TL) markers, particularly follicular T helper (Tfh) cells, may differentiate between responder and nonresponder alloimmunization statuses. We tested this hypothesis by studying the phenotype of CXCR5+PD1+ TLs in whole blood. Our results suggest that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33651102
DOI: 10.1182/bloodadvances.2020003537
PMCID: PMC7948298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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