Article
Identification of genetic biomarkers for alloimmunization in sickle cell disease.
British journal of haematology - 1 Sept 2019
Meinderts Sanne M, Gerritsma Jorn J, Sins Joep W R, de Boer Martin, van Leeuwen Karin, Biemond Bart J, Rijneveld Anita W, Kerkhoffs Jean-Louis H, Habibi Anoosha, van Bruggen Robin, Kuijpers Taco W, van der Schoot Ellen, Pirenne France, Fijnvandraat Karin, Tanck Michael W, van den Berg Timo K
Abstract excerpt
Most sickle cell disease (SCD) patients rely on blood transfusion as their main treatment strategy. However, frequent blood transfusion poses the risk of alloimmunization. On average, 30% of SCD patients will alloimmunize while other patient groups form antibodies less frequently. Identification of genetic markers may help to predict which patients are at risk to form alloantibodies. The aim of this study was to...
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