Article
Immune mechanisms involved in sickle cell disease pathogenesis: current knowledge and perspectives.
Immunology letters - 1 Aug 2020
de Azevedo Júlia Teixeira Cottas, Malmegrim Kelen Cristina Ribeiro
Abstract excerpt
Sickle cell disease (SCD) is caused by a single point mutation in the β-chain of the hemoglobin gene that results in the replacement of glutamic acid with valine in the hemoglobin protein. However, recent studies have demonstrated that alterations in several other genes, especially immune related genes, may be associated with complications of SCD. In fact, higher chronic inflammatory status is related to more...
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