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Article

Mechanisms of disease: motoneuron disease aggravated by transgenic expression of a functionally modified AMPA receptor subunit.

Annals of the New York Academy of Sciences - 1 Aug 2005

Kuner Rohini, Groom Anthony J, Müller Gerald, Kornau Hans-Christian, Stefovska Vanya, Bresink Iris, Hartmann Bettina, Tschauner Karsten, Waibel Stefan, Ludolph Albert C, Ikonomidou Chrysanthy, Seeburg Peter H, Turski Lechoslaw

Abstract excerpt

To reveal whether increased Ca2+ permeability of glutamate AMPA channels triggered by the transgene for GluR-B(N) induces decline in motor functions and neurodegeneration in the spinal cord, we evaluated growth, motor coordination, and spinal reflexes in transgenic GluR-B(N) and wild-type (wt) mice. To reveal whether the transgenic GluR-B(N) expression aggravates the course of motoneuron disease in SOD1 mice, we...

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PMID: 16179532
DOI: 10.1196/annals.1344.024

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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