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Article

Genetic mapping of a mouse modifier gene that can prevent ALS onset.

Genomics - 1 Dec 2000

Kunst C B, Messer L, Gordon J, Haines J, Patterson D

Abstract excerpt

Mutations in the cytoplasmic Cu/Zn superoxide dismutase (SOD1) gene on human chromosome 21q22.1 cause 10-20% of familial amyotrophic lateral sclerosis (ALS) cases. The expression of the ALS phenotype in mice carrying the murine G86R SOD1 mutation is highly dependent upon the mouse genetic background. This is similar to the phenotypic variation observed in ALS patients containing identical SOD1 mutations. In the...

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Identifiers

PMID: 11112346
DOI: 10.1006/geno.2000.6379

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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