Article
Paradigms for the identification of new genes in motor neuron degeneration.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases - 1 Dec 2003
Hafezparast Majid, Ahmad-Annuar Azlina, Hummerich Holger, Shah Paresh, Ford Melisa, Baker Cathy, Bowen Sam, Martin Joanne E, Fisher Elizabeth M C
Abstract excerpt
It is estimated that between 10-20% of amyotrophic lateral sclerosis (ALS) is familial and these cases encompass recessive and dominant modes of inheritance. So far, mutations in three genes, superoxide dismutase 1 (SOD1), the p150 subunit of dynactin (DCTN1), and alsin have been shown to be directly causal for motor neuron degeneration in humans. However, clearly the disorder is genetically heterogeneous and...
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