Article
Effect of CAR polymorphism on the pharmacokinetics of artemisinin in healthy Chinese subjects.
Drug metabolism and pharmacokinetics - 1 Feb 2015
Zang Meitong, Zhao Lixia, Zhu Fanping, Li Xinxiu, Yang Aijuan, Xing Jie
Abstract excerpt
Repeated pretreatment with the antimalarial drug artemisinin (QHS) could lead to reduced exposure to the parent drug, which is mainly mediated by auto-induction of CYP2B6 activity. CYP2B6 is most sensitive to the inductive effect of constitutive androstane receptor (CAR), which can be activated by QHS. CYP2B6 polymorphism has no influence on pharmacokinetics of QHS derivatives. This study aimed to investigate the...
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