HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

Abstract excerpt

For the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The reverse reaction, histone deacetylation, is mediated by histone deacetylases (HDACs) leading to chromatin...

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• Histone Deacetylase Inhibitors Research
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors