Article
Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Aug 2015
Minster Ryan L, Sanders Jason L, Singh Jatinder, Kammerer Candace M, Barmada M Michael, Matteini Amy M, Zhang Qunyuan, Wojczynski Mary K, Daw E Warwick, Brody Jennifer A, Arnold Alice M, Lunetta Kathryn L, Murabito Joanne M, Christensen Kaare, Perls Thomas T, Province Michael A, Newman Anne B
Abstract excerpt
BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide...
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