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Article

Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance.

PLoS genetics - 1 Mar 2015

Esparza-Gordillo Jorge, Matanovic Anja, Marenholz Ingo, Bauerfeind Anja, Rohde Klaus, Nemat Katja, Lee-Kirsch Min-Ae, Nordenskjöld Magnus, Winge Marten C G, Keil Thomas, Krüger Renate, Lau Susanne, Beyer Kirsten, Kalb Birgit, Niggemann Bodo, Hübner Norbert, Cordell Heather J, Bradley Maria, Lee Young-Ae

Abstract excerpt

Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development. Loss-of-function mutations in the filaggrin gene (FLG) cause skin barrier deficiency and...

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Identifiers

PMID: 25757221
DOI: 10.1371/journal.pgen.1005076
PMCID: PMC4355615

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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