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Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy

10 Mar 2015

Abstract excerpt

A familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy is described in 2 sisters born from consanguineous parents. The neuropathologic examination revealed massive accumulation of abnormally hyperphosphorylated, conformational, truncated tau at aspartic acid 421, ubiquitinated and nitrated tau at Tyr29 in cortical astrocyte (including their perivascular foot...

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PMID: 25756587
DOI: 10.1097/nen.0000000000000180

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