Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.

doi:10.1023/a:1008209720526

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Article

Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 1997

Voldborg B R, Damstrup L, Spang-Thomsen M, Poulsen H S

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intr...

Topics

Clinical Trials as Topic
ErbB Receptors
Gene Deletion
Humans
Mutation
Neoplasms
Phenotype
Signal Transduction

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