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Article

Inducible ATF3–NFAT axis aggravates podocyte injury

16 Oct 2017

Abstract excerpt

Podocyte injury and loss contribute to proteinuria, glomerulosclerosis, and eventually kidney failure. Activating transcription factor 3 (ATF3) is a stress inducible transcription factor that is transiently expressed following stimulation. However, we show for the first time an induction of ATF3 in podocytes from patients with chronic kidney disease, including minimal change disease, focal segmental...

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PMID: 29038896
DOI: 10.1007/s00109-017-1601-x

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