Article

The apoptosis gene <i>BCL-X</i> splice isoforms have opposing effects in diabetic kidney disease: potential treatment target and prognostic value

2025-06-07

Abstract excerpt

In recent years, the importance of alternative splicing (AS) of certain genes in the nature and progression of diabetic nephropathy (DN) has been studied. We report a novel AS event observed in the diabetic kidney – AS of the apoptosis gene BCL-X to increase the pro-apoptotic BCL-XS and decrease the anti-apoptotic BCL-XL . This study aimed to further investigate the role of this novel AS event in the pathogenes...

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Literature Corpus work: f853c4ad-38b2-5c91-be31-ec6719032796
DOI: 10.1101/2025.06.06.658276

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The apoptosis gene <i>BCL-X</i> splice isoforms have opposing effects in diabetic kidney disease: potential treatment target and prognostic valueDOI 10.1101/2025.06.06.658276Read

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