Article
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.
The Journal of biological chemistry - 11 Jun 2010
Liu Ning, Li Hui, Li Shuangxi, Shen Mingyue, Xiao Ning, Chen Yunfei, Wang Yan, Wang Weichao, Wang Rui, Wang Qian, Sun Jianhua, Wang Ping
Abstract excerpt
The proproliferative transcription factor KLF5 plays an important role in promoting cell proliferation and tumorigenesis. KLF5 is a short-lived protein that can be rapidly degraded through the ubiquitin-proteasome pathway in cancer cells. However, the mechanisms regulating protein stability remain poorly understood. In this study, the tumor suppressor Fbw7, a component of the SCF complex (SCF(Fbw7)) E3 ubiquitin...
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