Article
Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults.
Respiratory investigation - 1 Mar 2015
Yamada Hideyasu, Yatagai Yohei, Masuko Hironori, Sakamoto Tohru, Iijima Hiroaki, Naito Takashi, Noguchi Emiko, Hirota Tomomitsu, Tamari Mayumi, Hizawa Nobuyuki
Abstract excerpt
BACKGROUND: Pulmonary function is a heritable trait, and recent genome-wide association studies (GWASs) have identified a number of loci influencing the trait. Genome-wide Complex Trait Analysis (GCTA) is a novel method provided by a software package that estimates the total additive genetic influence caused by common single nucleotide polymorphisms (SNPs) on whole-genome arrays. We conducted a GWAS and assessed...
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