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Cancer stem cells, a fuzzy evolving concept: A cell population or a cell property?

3 Dec 2013

Abstract excerpt

The cancer stem cells (CSC) hypothesis represents a pathological extrapolation of the physiological concept of embryonic and somatic stem cells. In its initial definition, it encompassed the hypothesis of a qualitatively distinct population of immortal cancer cells originating from somatic stem cells, which generate in xenotransplants by a deterministic irreversible process, the hierarchy of more differentiated...

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PMID: 24270846
DOI: 10.4161/cc.27305

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