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Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes

5 Mar 2015

Abstract excerpt

BACKGROUND: Somatic mutations affecting components of the Ras-MAPK pathway are a common feature of cancer, whereas germline Ras pathway mutations cause developmental disorders including Noonan, Costello, and cardio-facio-cutaneous syndromes. These 'RASopathies' also represent cancer-prone syndromes, but the quantitative cancer risks remain unknown. METHODS: We investigated the occurrence of childhood cancer...

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PMID: 25742478
DOI: 10.1038/bjc.2015.75

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