Article
Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2024
Perrino Melissa R, Das Anirban, Scollon Sarah R, Mitchell Sarah G, Greer Mary-Louise C, Yohe Marielle E, Hansford Jordan R, Kalish Jennifer M, Schultz Kris Ann P, MacFarland Suzanne P, Kohlmann Wendy K, Lupo Philip J, Maxwell Kara N, Pfister Stefan M, Weksberg Rosanna, Michaeli Orli, Jongmans Marjolijn C J, Tomlinson Gail E, Brzezinski Jack, Tabori Uri, Ney Gina M, Gripp Karen W, Gross Andrea M, Widemann Brigitte C, Stewart Douglas R, Woodward Emma R, Kratz Christian P
Abstract excerpt
Neurofibromatosis type 1 (NF1), Noonan syndrome, and related syndromes, grouped as RASopathies, result from dysregulation of the RAS-MAPK pathway and demonstrate varied multisystemic clinical phenotypes. Together, RASopathies are among the more prevalent genetic cancer predisposition syndromes and require nuanced clinical management. When compared with the general population, children with RASopathies are at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.