Interferon-λ rs12979860 genotype association with liver fibrosis in chronic hepatitis C (CHC) patients in the Pakistani population.

doi:10.1007/s00705-020-04901-2

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Interferon-λ rs12979860 genotype association with liver fibrosis in chronic hepatitis C (CHC) patients in the Pakistani population.

Archives of virology - 1 Apr 2021

Rauff Bisma, Amar Ali, Chudhary Shafiq Ahmad, Mahmood Saqib, Tayyab Ghias Un Nabi, Hanif Rumeza

Abstract excerpt

Risk and progression of liver fibrosis and cirrhosis in chronic hepatitis C (CHC) patients is significantly influenced by host genetic factors in a polygenic manner. The rs12979860 genetic polymorphism in the interferon-λ3-interferon-λ4 (IFNL3-IFNL4) region has been found to be a major determinant of hepatic inflammatory and fibrotic progression in CHC patients of mainly Caucasian origin; however, it is not known...

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PMID: 33528661
DOI: 10.1007/s00705-020-04901-2

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