Article
Methods for association analysis and meta-analysis of rare variants in families.
Genetic epidemiology - 1 May 2015
Feng Shuang, Pistis Giorgio, Zhang He, Zawistowski Matthew, Mulas Antonella, Zoledziewska Magdalena, Holmen Oddgeir L, Busonero Fabio, Sanna Serena, Hveem Kristian, Willer Cristen, Cucca Francesco, Liu Dajiang J, Abecasis Gonçalo R
Abstract excerpt
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety of association tests that group variants by gene or functional unit have been proposed. Here, we extend these tests to family-based studies. We develop family-based burden tests, variable...
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