Article
Human adaptation to arsenic-rich environments.
Molecular biology and evolution - 1 Jun 2015
Schlebusch Carina M, Gattepaille Lucie M, Engström Karin, Vahter Marie, Jakobsson Mattias, Broberg Karin
Abstract excerpt
Adaptation drives genomic changes; however, evidence of specific adaptations in humans remains limited. We found that inhabitants of the northern Argentinean Andes, an arid region where elevated arsenic concentrations in available drinking water is common, have unique arsenic metabolism, with efficient methylation and excretion of the major metabolite dimethylated arsenic and a less excretion of the highly toxic...
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