Article
Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population.
Environmental and molecular mutagenesis - 1 Jul 2017
de la Rosa Rosemarie, Steinmaus Craig, Akers Nicholas K, Conde Lucia, Ferreccio Catterina, Kalman David, Zhang Kevin R, Skibola Christine F, Smith Allan H, Zhang Luoping, Smith Martyn T
Abstract excerpt
Inter-individual differences in arsenic metabolism have been linked to arsenic-related disease risks. Arsenic (+3) methyltransferase (AS3MT) is the primary enzyme involved in arsenic metabolism, and we previously demonstrated in vitro that N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) also methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic...
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