Article
MiR-21 controls in situ expansion of CCR6⁺ regulatory T cells through PTEN/AKT pathway in breast cancer.
Immunology and cell biology - 1 Sept 2015
Hu Yan, Wang Chunhong, Li Yongju, Zhao Juanjuan, Chen Chao, Zhou Ya, Tao Yijin, Guo Mengmeng, Qin Nalin, Ren Tao, Wen Zhenke, Xu Lin
Abstract excerpt
Our recent evidence showed that prior expansion of CCR6(+) Foxp3(+) regulatory T cells (Tregs) was important for their dominant enrichment in tumor tissue, which was closely related to poor prognosis of breast cancer patients. However, the underlying regulation mechanism of expansion of CCR6(+) Tregs in situ remains largely unknown. In this study, we reported that miR-21 was highly expressed in CCR6(+) Tregs in...
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