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Article

Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population.

The Journal of urology - 1 Jun 2003

Li Zhenhua, Habuchi Tomonori, Mitsumori Kenji, Kamoto Toshiyuki, Kinoshitu Hidefumi, Segawa Takehiko, Ogawa Osamu, Kato Tetsuro

Abstract excerpt

PURPOSE: The SRD5A2 gene codes the steroid 5-reductase type II, a critical mediator of androgen action, and the V89L and A49T polymorphisms of this gene may be associated with a distinct enzyme activity. We explored the association among these polymorphisms and the risk of prostate cancer or benign prostatic hyperplasia (BPH) in a Japanese population. MATERIALS AND METHODS: This study included 302 patients with...

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Identifiers

PMID: 12771801
DOI: 10.1097/01.ju.0000056152.57018.31

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population.PMID 12771801Read ↗

SRD5A2 V89L polymorphism and prostate cancer risk: a meta-analysis.Semantic proximity Read ↗

[V89L polymorphism of the testosterone 5-alpha-reductase II gene and prognostic factors of prostate cancer].Semantic proximity Read ↗

Polymorphism of the SRD5A2 gene and the risk of prostate cancer.Semantic proximity Read ↗

Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study.Semantic proximity Read ↗

Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in the 5alpha reductase type 2 gene and urologic measures of BPH.Semantic proximity Read ↗

Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review.Semantic proximity Read ↗

SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysis.Semantic proximity Read ↗

Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer.Semantic proximity Read ↗

SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.Semantic proximity Read ↗

Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population.Semantic proximity Read ↗

Longer (TA)n repeat but not A49T and V89L polymorphisms in SRD5A2 gene may confer prostate cancer risk in South Indian men.Semantic proximity Read ↗

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