Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of human androgens and prostatic diseases.

Pharmacogenomics - 1 Feb 2001

Novelli G, Margiotti K, Sangiuolo F, Reichardt J K

Abstract excerpt

Prostate cancer (PCa) and benign prostatic hypertrophy (BPH) are two common and growing public health problems in the Western world. We review here the recent biochemical and pharmacogenetic literature related to these two prostatic disorders. We focus first on constitutional ('germline') single nucleotide polymorphism (SNPs) at the steroid 5 alpha-reductase (SRD5A2) locus, which encodes the human prostatic (or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Share to Prostatic Hyperplasia

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Source

Identifiers

PMID: 11258198
DOI: 10.1517/14622416.2.1.65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of human androgens and prostatic diseases.PMID 11258198Read ↗

Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue.Semantic proximity Read ↗

Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development.Semantic proximity Read ↗

GEN GEN: the genomic genetic analysis of androgen-metabolic genes and prostate cancer as a paradigm for the dissection of complex phenotypes.Semantic proximity Read ↗

SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.Semantic proximity Read ↗

Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the Prostate Cancer Prevention Trial.Semantic proximity Read ↗

Androgens and the molecular epidemiology of prostate cancer.Semantic proximity Read ↗

Biochemical and pharmacogenetic dissection of human steroid 5??-reductase type IISemantic proximity Read ↗

Prostatic steroid 5 alpha-reductase, an androgen metabolic gene.Semantic proximity Read ↗

A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.Semantic proximity Read ↗

Polymorphisms in Genes Involved in Androgen Pathways as Risk Factors for Prostate CancerSemantic proximity Read ↗

Genotyping of sex hormone-related pathways in benign and malignant human prostate tissues: data of a preliminary study.Semantic proximity Read ↗

5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.