Molecular Analysis of the SRD5A1 and SRD5A2 Genes in Patients with Benign Prostatic Hyperplasia with Regard to Metabolic Parameters and Selected Hormone Levels.

doi:10.3390/ijerph14111318

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Article

Molecular Analysis of the SRD5A1 and SRD5A2 Genes in Patients with Benign Prostatic Hyperplasia with Regard to Metabolic Parameters and Selected Hormone Levels.

International journal of environmental research and public health - 30 Oct 2017

Rył Aleksandra, Rotter Iwona, Grzywacz Anna, Małecka Iwona, Skonieczna-Żydecka Karolina, Grzesiak Katarzyna, Słojewski Marcin, Szylińska Aleksandra, Sipak-Szmigiel Olimpia, Piasecka Małgorzata, Walczakiewicz Kinga, Laszczyńska Maria

Abstract excerpt

Introduction: The etiology of benign prostatic hyperplasia (BPH) has not so far been fully explicated. However, it is assumed that changes in the levels of hormones associated with aging can contribute to the development of prostatic hyperplasia. Dihydrotestosterone combines with the androgen receptor (AR) proteins of the prostate gland. Enzyme activity is based on two isoenzymes: type 1 and type 2. 5α-reductase...

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PMID: 29084161
DOI: 10.3390/ijerph14111318
PMCID: PMC5707957

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SHBG

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