Article
The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.
European urology - 1 Oct 2005
Giwercman Yvonne L, Abrahamsson Per-Anders, Giwercman Aleksander, Gadaleanu Virgil, Ahlgren Göran
Abstract excerpt
OBJECTIVES: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5alpha-reductase II (SRD5A2) gene. MATERIALS AND METHODS: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n=89), benign prostate hyperplasia (n=45)...
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