Article
Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2005
Aoki Hitomi, Motohashi Tsutomu, Yoshimura Naoko, Yamazaki Hidetoshi, Yamane Toshiyuki, Panthier J J, Kunisada Takahiro
Abstract excerpt
The development of melanocytes from neural crest-derived precursor cells depends on signaling by the receptor tyrosine kinase KIT and the G protein-coupled endothelin receptor B (EDNRB) pathways. Loss-of-function mutations in either of these two signaling receptor molecules cause a loss or a marked reduction in the number of melanocyte precursors in the embryo and finally lead to loss of the coat color. Using...
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