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Article

KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.

Antiviral research - 1 Jul 2005

Harris Kevin S, Brabant William, Styrchak Sheila, Gall Alexander, Daifuku Richard

Abstract excerpt

We report the activities of a novel nucleoside analog against HIV. This nucleoside (KP-1212) is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome. Serial passaging of HIV in the presence of KP-1212 causes an increase in the mutation rate of the virus leading to viral ablation. HIV strains resistant to KP-1212 have not yet been isolated. Quite to the contrary, virus...

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Identifiers

PMID: 15890415
DOI: 10.1016/j.antiviral.2005.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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