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Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis

1 Mar 2015

Abstract excerpt

OBJECTIVE: IL-35 is the most recently identified member of the IL-12 family. It consists of EBV-induced gene 3 (EBI3) and IL-12α chain p35. We investigated whether IL-35 enhances the in vitro immunosuppressive function of peripheral blood isolated from patients with RA. METHODS: Peripheral blood was harvested from 17 active and 10 inactive RA patients and IL-35 concentrations were quantified using an ELISA. An...

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PMID: 25731770
DOI: 10.1093/rheumatology/keu528

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