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Article

Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.

European journal of immunology - 1 Jun 2015

Dixon Karen O, van der Kooij Sandra W, Vignali Dario A A, van Kooten Cees

Abstract excerpt

IL-35 is a cytokine of the IL-12 family, existing as a heterodimer of IL-12p35 and Ebi3. IL-35 has anti-inflammatory properties and is produced by regulatory T cells in humans and mice, where it is required for optimal suppression of immune responses. Distinct from other IL-12 cytokines, the expression of IL-35 has not been described in antigen-presenting cells. In view of the immune-regulatory properties of...

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Identifiers

PMID: 25820702
DOI: 10.1002/eji.201445217
PMCID: PMC4617619

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