Article
The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFcγRIIbhi Regulatory B-Cell Subset in Lupus.
The Journal of investigative dermatology - 1 Dec 2017
Zhang Yamin, Li Jun, Zhou Nuoya, Zhang Yi, Wu Min, Xu Jian, Shen Chen, An Xiangjie, Shen Guanxin, Yang Ming, Zhang Chun, Tao Juan
Abstract excerpt
IL-35 is a critical immunosuppressive cytokine that plays an important role in various autoimmune diseases. The purpose of this study was to determine whether BAFF, a key pathogenic factor in systemic lupus erythematosus, also a dichotomous regulator for B-cell immune responses, has an effect on IL-35-producing regulatory B cells and their underlying mechanisms in lupus. We found that exogenous BAFF could induce...
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