Article
Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population.
Genetics and molecular research : GMR - 23 Jan 2015
Ramírez-Ramírez R, Gutiérrez-Angulo M, Magaña M T, Moreno-Ortiz J M, Partida-Pérez M, Muñiz-Mendoza R, Peregrina-Sandoval J, Suárez-Villanueva A S, Centeno-Flores M, Maciel-Gutiérrez V M, Cabrales-Vazquez E, Ayala-Madrigal M L
Abstract excerpt
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed the 2 polymorphisms in Mexican patients with CRC....
Read the complete abstract on PubMed