Article
m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction.
Diabetes - 1 Mar 2009
Lindroos Markus M, Majamaa Kari, Tura Andrea, Mari Andrea, Kalliokoski Kari K, Taittonen Markku T, Iozzo Patricia, Nuutila Pirjo
Abstract excerpt
OBJECTIVE: To study insulin sensitivity and perfusion in skeletal muscle together with the beta-cell function in subjects with the m.3243A>G mutation in mitochondrial DNA, the most common cause of mitochondrial diabetes. RESEARCH DESIGN AND METHODS: We measured skeletal muscle glucose uptake and perfusion using positron emission tomography and 2-[18F]fluoro-2-deoxyglucose and [15O]H2O during euglycemic...
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