Article
C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen.
FEBS letters - 24 Mar 2015
Takahashi Soichiro, Watanabe Kazuhiro, Watanabe Yosuke, Fujioka Daisuke, Nakamura Takamitsu, Nakamura Kazuto, Obata Jun-ei, Kugiyama Kiyotaka
Abstract excerpt
Phospholipase A2 receptor 1 (PLA2R) mediates collagen-dependent migration. The mechanisms by which PLA2R interacts with collagen remain unclear. We produced HEK293 cells expressing full-length wild-type PLA2R or a truncated PLA2R that lacks fibronectin-like type II (FNII) domains or several regions of C-type lectin-like domain (CTLD). We show that the CTLD1-2 as well as the FNII domain of PLA2R are responsible...
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