Article
Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen.
Experimental cell research - 1 Nov 2008
Vuoriluoto Karoliina, Jokinen Johanna, Kallio Katja, Salmivirta Markku, Heino Jyrki, Ivaska Johanna
Abstract excerpt
Several different receptor molecules act in concert to regulate cell adhesion. Among these are cell-surface proteoglycans and integrins, which collaborate extensively in mediating binding of cells to extracellular matrix molecules fibronectin and vitronectin. However, very little is known about possible functional synergism between proteoglycans and integrins during adhesion of cells to collagen, although...
Topics
- Actins
- Animals
- CHO Cells
- Cell Adhesion
- Cell Line
- Collagen
- Cricetinae
- Cricetulus
- Flow Cytometry
- Fluorescent Antibody Technique
- Heparan Sulfate Proteoglycans
- Integrin alpha2beta1
- Mutation
- Peptides
- Reverse Transcriptase Polymerase Chain Reaction
- Syndecan-1
- Transfection
- Up-Regulation
