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MeCP2 epigenetically regulates alpha‐smooth muscle actin in human lung fibroblasts

1 Mar 2020

Abstract excerpt

BACKGROUND: A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (MeCP2) interacts with CpG-rich region in α-SMA, and if the CpG methylation status would affect...

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PMID: 32115750
DOI: 10.1002/jcb.29655

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