Article
Alterations of the Sialylation Machinery in Brugada Syndrome.
International journal of molecular sciences - 29 Oct 2022
Ghiroldi Andrea, Ciconte Giuseppe, Creo Pasquale, Tarantino Adriana, Melgari Dario, D'Imperio Sara, Piccoli Marco, Cirillo Federica, Micaglio Emanuele, Monasky Michelle M, Frosio Anthony, Locati Emanuela T, Vicedomini Gabriele, Rivolta Ilaria, Pappone Carlo, Anastasia Luigi
Abstract excerpt
Brugada Syndrome (BrS) is an inherited arrhythmogenic disorder with an increased risk of sudden cardiac death. Recent evidence suggests that BrS should be considered as an oligogenic or polygenic condition. Mutations in genes associated with BrS are found in about one-third of patients and they mainly disrupt the cardiac sodium channel NaV1.5, which is considered the main cause of the disease. However,...
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