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Article

The β1-subunit of Na(v)1.5 cardiac sodium channel is required for a dominant negative effect through α-α interaction.

PloS one - 1 Jan 2012

Mercier Aurélie, Clément Romain, Harnois Thomas, Bourmeyster Nicolas, Faivre Jean-François, Findlay Ian, Chahine Mohamed, Bois Patrick, Chatelier Aurélien

Abstract excerpt

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy. Several mutations on the cardiac sodium channel Na(v)1.5 which are responsible for BrS lead to misfolded proteins that do not traffic properly to the plasma membrane. In order to mimic patient heterozygosity, a trafficking defective mutant, R1432G was co-expressed with Wild Type (WT) Na(v)1.5 channels in HEK293T cells. This mutant...

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Identifiers

PMID: 23133651
DOI: 10.1371/journal.pone.0048690
PMCID: PMC3486797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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