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Article

Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.

Nucleic acids research - 5 May 2016

Quilez Javier, Guilmatre Audrey, Garg Paras, Highnam Gareth, Gymrek Melissa, Erlich Yaniv, Joshi Ricky S, Mittelman David, Sharp Andrew J

Abstract excerpt

Despite representing an important source of genetic variation, tandem repeats (TRs) remain poorly studied due to technical difficulties. We hypothesized that TRs can operate as expression (eQTLs) and methylation (mQTLs) quantitative trait loci. To test this we analyzed the effect of variation at 4849 promoter-associated TRs, genotyped in 120 individuals, on neighboring gene expression and DNA methylation....

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Share to DNA Methylation
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Linkage Disequilibrium

Share to Promoter Regions, Genetic

Share to Quantitative Trait Loci

Share to Sequence Analysis, DNA

Share to Tandem Repeat Sequences

Source

Open in PubMed Open full text

Identifiers

PMID: 27060133
DOI: 10.1093/nar/gkw219
PMCID: PMC4857002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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