Article
Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice.
Molecular medicine (Cambridge, Mass.) - 12 Mar 2025
Bao Yantao, Wu Weiqing, Lin Jiyun, Yang Yuankai, Lin Sheng, Su Jindi, Qin Yueyuan, Wang Baojiang, Duan Shan
Abstract excerpt
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal disease, the mechanism of which remains unclear. Renal fibrosis is a characteristic pathology observed in XLAS kidney tissue. However, the molecular path from COL4A5...
Read the complete abstract on PubMedTopics
- Animals
- Hyaluronan Receptors
- Collagen Type IV
- Nephritis, Hereditary
- Mice
- Hyaluronic Acid