Article
[A study of IL-1Β and IDO gene polymorphisms in patients with schizophrenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2014
Golimbet V E, Korovaĭtseva G I, Gabaeva M V, Velikaia N V, Snegireva A A, Kasparov S V, Kolesina N Iu, Ganisheva T K, Savel'eva T M
Abstract excerpt
OBJECTIVE: Neurotoxic metabolites of the kynurenine pathway are thought to be implicated in the pathogenesis of schizophrenia. The enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step of the kynurenine pathway that converts tryptophan to kynurenine metabolites. IDO is induced by proinflammatory cytokines. We studied IL-1Β T-511C (rs16944), IL-1Β C3954T (rs1143634), IDO VNTR and IDO rs9657182...
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