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Article

Fluorescence-based detection of single-nucleotide changes in RNA using graphene oxide and DNAzyme.

Chemical communications (Cambridge, England) - 4 Apr 2015

Hong Chaesun, Kim Dong-Min, Baek Ahruem, Chung Hyewon, Jung Woong, Kim Dong-Eun

Abstract excerpt

We report a simple fluorometric method for detection of single-nucleotide changes in RNA using graphene oxide (GO) and RNA-cleaving DNAzyme. The fluorescent DNA probe (F-DNA) was annealed to RNA fragments generated by RNA cleavage with DNAzyme specific to mutant RNA. The F-DNA-RNA duplex attenuated the quenching of F-DNA fluorescence by GO.

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Identifiers

PMID: 25714982
DOI: 10.1039/c4cc09603g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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